5xeg

The structure of OsALKBH1

spinqualitylabelsall models 5xeg, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xeg is a 1 chain structure with sequence from Oryza sativa Japonica Group. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: AKG, MN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q10BI6_ORYSJ Publication Abstract from PubMed DNA N(6)-methyladenine (6mA) is a non-canonical DNA modification that is present at low levels in different eukaryotes(1-8), but its prevalence and genomic function in higher plants are unclear. Using mass spectrometry, immunoprecipitation and validation with analysis of single-molecule real-time sequencing, we observed that about 0.2% of all adenines are 6mA methylated in the rice genome. 6mA occurs most frequently at GAGG motifs and is mapped to about 20% of genes and 14% of transposable elements. In promoters, 6mA marks silent genes, but in bodies correlates with gene activity. 6mA overlaps with 5-methylcytosine (5mC) at CG sites in gene bodies and is complementary to 5mC at CHH sites in transposable elements. We show that OsALKBH1 may be potentially involved in 6mA demethylation in rice. The results suggest that 6mA is complementary to 5mC as an epigenomic mark in rice and reinforce a distinct role for 6mA as a gene expression-associated epigenomic mark in eukaryotes. Identification and analysis of adenine N(6)-methylation sites in the rice genome.,Zhou C, Wang C, Liu H, Zhou Q, Liu Q, Guo Y, Peng T, Song J, Zhang J, Chen L, Zhao Y, Zeng Z, Zhou DX Nat Plants. 2018 Aug;4(8):554-563. doi: 10.1038/s41477-018-0214-x. Epub 2018 Jul , 30. PMID:30061746 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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