5xeu

crystal structure of Hcp2 from Salmonella typhimurium

spinqualitylabelsall models 5xeu, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xeu is a 6 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function H9L4J8_SALTM Publication Abstract from PubMed STM0279 is a putative cytoplasmic protein from Salmonella typhimurium and was recently renamed haemolysin co-regulated protein 2 (Hcp2), with the neighbouring STM0276 being Hcp1. Both of them are encoded by the type VI secretion system (T6SS) of the Salmonella pathogenicity island 6 (SPI-6) locus and have high sequence identity. The Hcp proteins may function as a vital component of the T6SS nanotube and as a transporter and chaperone of diverse effectors from the bacterial T6SS. In this study, the crystal structure and the oligomeric state in solution of Hcp2 from S. typhimurium (StHcp2) were investigated. The crystal structure refined to 3.0 A resolution showed that the protein is composed of a beta-barrel domain with extended loops and can form hexameric rings as observed in known Hcp homologues. Mutation of the extended loop was found to partly destabilize the hexameric conformation into monomers or cause the production of inclusion bodies, suggesting it has an important role in hexameric ring formation. Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium.,Lin QP, Gao ZQ, Geng Z, Zhang H, Dong YH Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):463-468. doi:, 10.1107/S2053230X17010512. Epub 2017 Jul 26. PMID:28777089 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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