5xic

Crystal Structure of HasAp with Fe-5,10,15-triphenylporphyrin

spinqualitylabelsall models 5xic, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xic is a 4 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.45Å Ligands: PE8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G3XD33_PSEAE Publication Abstract from PubMed Iron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency. Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group.,Uehara H, Shisaka Y, Nishimura T, Sugimoto H, Shiro Y, Miyake Y, Shinokubo H, Watanabe Y, Shoji O Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15279-15283. doi:, 10.1002/anie.201707212. Epub 2017 Oct 9. PMID:28921809 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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