5xtw

Crystal structure of the CysR-CTLD2 fragment of human MR at acidic pH

spinqualitylabelsall models 5xtw, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xtw is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Ligands: CA, MES Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MRC1_HUMAN Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. Publication Abstract from PubMed Mannose receptor (MR, CD206) is an endocytic receptor on microphages and dendritic cells. It recognizes multiple ligands and plays important roles in regulating immune responses and maintaining glycoprotein homeostasis. However, the structure and functional mechanism of MR remain unclear. Here we determine the crystal structures of the N-terminal fragments of MR and reveal the potential binding mode of collagen on the fibronectin II domain. The SAXS and other biophysical data suggest that MR adopts an extended conformation at physiological pH and undergoes conformational changes as pH decreases, resulting in a compact conformation in an acidic environment. Moreover, biochemical data show that MR binds to collagen in a Ca(2+)-enhanced manner at physiological pH, whereas Ca(2+) has no effect on the binding at acidic pH. These results provide a model for the dynamic mechanism of MR regarding its ligand binding and release during the recycling between cell surface and endosomes. Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor.,Hu Z, Shi X, Yu B, Li N, Huang Y, He Y Structure. 2017 Dec 6. pii: S0969-2126(17)30359-3. doi:, 10.1016/j.str.2017.11.006. PMID:29225077 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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