5xz3

The X-ray structure of Apis mellifera PGRP-SA

spinqualitylabelsall models 5xz3, resolution 1.86Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xz3 is a 4 chain structure with sequence from Apis mellifera. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.86Å Ligands: SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Peptidoglycan recognition protein SA (PGRP-SA) is a key pattern recognition receptor in the insect innate immune system. PGRP-SA can bind to bacterial PGN and activate the Toll pathway, which triggers the expression and release of antimicrobial peptides to prevent bacterial infection. Here, we report the first structure of Apis mellifera PGRP-SA from Hymenoptera at 1.86 A resolution. The overall architecture of Am-PGRP-SA was similar to the Drosophila PGRP-SA; however, the residues involved in PGN binding groove were not conserved, and the binding pocket was narrower. This structure gives insight into PGN binding characteristics in honeybees. Crystal structure of peptidoglycan recognition protein SA in Apis mellifera (Hymenoptera: Apidae).,Liu Y, Zhao X, Naeem M, An J Protein Sci. 2018 Apr;27(4):893-897. doi: 10.1002/pro.3383. Epub 2018 Mar 14. PMID:29396863 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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