5y06

Structural characterization of msmeg_4306 from Mycobacterium smegmatis

spinqualitylabelsall models 5y06, resolution 2.61Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5y06 is a 1 chain structure with sequence from Mycolicibacterium smegmatis MC2 155. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.606Å Ligands: GOL, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0R095_MYCS2 Publication Abstract from PubMed The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino-acid residues that contains a conserved zinc-ribbon domain at its C-terminus. Here, the crystal structure of MSMEG_4306 determined by the single-wavelength anomalous dispersion method using just one zinc ion co-purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled-coil helix domain in the N-terminal region and a zinc-ribbon domain in the C-terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori, although they share only approximately 15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids. Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis.,Kumar A, Karthikeyan S Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):166-173. doi:, 10.1107/S2053230X18002236. Epub 2018 Feb 26. PMID:29497021 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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