5y7i

Structure of tilapia fish CLIC2

spinqualitylabelsall models 5y7i, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5y7i is a 2 chain structure with sequence from Oreochromis mossambicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A239S009_OREMO Publication Abstract from PubMed Chloride intracellular channels (CLICs) exist in soluble and membrane bound forms. We have determined the crystal structure of soluble Clic2 from the euryhaline teleost fish Oreochromis mossambicus. Structural comparison of tilapia and human CLIC2 with other CLICs shows that these proteins are highly conserved. We have also compared the expression levels of clic2 in selected osmoregulatory organs of tilapia, acclimated to freshwater, seawater and hypersaline water. Structural conservation of vertebrate CLICs implies that they might play conserved roles. Also, tissue-specific responsiveness of clic2 suggests that it might be involved in iono-osmoregulation under extreme conditions in tilapia. Tilapia and human CLIC2 structures are highly conserved.,Zeng J, Li Z, Lui EY, Lam SH, Swaminathan K Biochem Biophys Res Commun. 2018 Jan 8;495(2):1752-1757. doi:, 10.1016/j.bbrc.2017.11.189. Epub 2017 Dec 2. PMID:29198705 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ion channels 3D structures

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