5zc3

The Crystal Structure of PcRxLR12

spinqualitylabelsall models 5zc3, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5zc3 is a 2 chain structure with sequence from Phytophthora capsici. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.005Å Ligands: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A3F2YLV0_PHYCP Publication Abstract from PubMed RxLR genes are a prominent class of effectors in oomycetes, and almost half of these proteins contain a conserved sequence motif termed the WY domain, that may exist singly, or as divergent tandem repeats in different effectors. Here we describe the crystal structure of PcRxLR12 (63-488) from Phytophthora capsici at 3.0A resolution. The structure consists of five tandemly arrayed WY-domains linked to each other by short connecting helices. Superposition of the WY-2 domain on the other four domains of PcRxLR12, show that the first alpha-helix termed the K motif, and Loop 3 which connects alpha3 and alpha4 are the key regions of structural divergence between the WY domains. A similar pattern was observed when WY-2 was superposed on the 11 WY domains from other oomycete effectors. We also note that an added connecting helix between WY domains in some RXLR effectors, ensures that the WY domains are oriented in the same direction. Crystal structure of the RxLR effector PcRxLR12 from Phytophthora capsici.,Zhao L, Zhang X, Zhang X, Song W, Li X, Feng R, Yang C, Huang Z, Zhu C Biochem Biophys Res Commun. 2018 Aug 1. pii: S0006-291X(18)31623-1. doi:, 10.1016/j.bbrc.2018.07.121. PMID:30077372 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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