5zhq | pdb_00005zhq

Crystal structure of Scylla paramamosain arginine kinase

spinqualitylabelsall models 5zhq, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5zhq is a 2 chain structure with sequence from Scylla paramamosain. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.002Å Ligands: SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function KARG0_SCYPA Catalyzes the reversible transfer of high energy ATP gamma-phosphate group to L-arginine.[UniProtKB:C9EIP1] Publication Abstract from PubMed Shellfish are one of the most common causes of food allergy. Arginine kinase (AK) is known as an important allergen in shellfish. In the present study, AK from crab (Scylla paramamosain) was purified and its crystal structure was determined. A comparison of AK from S. paramamosain to AKs of other species showed high amino acid sequence and secondary structure identity, while the superposition of crystal structures of AKs from different species revealed only slight differences. Similarity of the linear epitope regions among species was observed in the epitope alignment of AKs; conformational epitopes were located in the regions where secondary structure was conserved. The structure of S. paramamosain AK is an accurate template for the analysis of the IgE binding pattern, and the structure conservation and epitope similarity of AKs among species could help to inform our understanding of the cross-reactivity and contribute to the prediction of cross-reactivity related epitopes. Crystal structure determination of Scylla paramamosain arginine kinase, an allergen that may cause cross-reactivity among invertebrates.,Yang Y, Liu GY, Yang H, Hu MJ, Cao MJ, Su WJ, Jin T, Liu GM Food Chem. 2019 Jan 15;271:597-605. doi: 10.1016/j.foodchem.2018.08.003. Epub, 2018 Aug 2. PMID:30236721 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Arginine kinase 3D structures

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