5zkx

The postfusion structure of human-infecting Bourbon virus envelope glycoprotein

spinqualitylabelsall models 5zkx, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5zkx is a 3 chain structure with sequence from Bourbon virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A140H4W8_9ORTO Publication Abstract from PubMed Thogotoviruses are important zoonotic viruses infecting a variety of domestic animals, as well as humans. Among these viruses, Bourbon virus (BRBV) is one of the several human-infecting members, which emerged in the US in recent years and caused human deaths. Here, we report the crystal structure of the BRBV envelope glycoprotein in the postfusion conformation. The structure adopts the typical fold of a class III viral fusion protein and displays an extensive positively charged electrostatic potential pattern, which resembles the glycoprotein of Dhori virus and is consistent with our previous predictions. In addition, compared to other previously defined class III viral fusion proteins, the structures of all thogotovirus glycoproteins and homologs are more similar to herpes virus glycoprotein Bs than to the rhabdovirus G proteins. Thus, class III viral fusion proteins are quite diverse in structure, and sub-classes may have developed during evolution. Postfusion structure of human-infecting Bourbon virus envelope glycoprotein.,Bai C, Qi J, Wu Y, Wang X, Gao GF, Peng R, Gao F J Struct Biol. 2019 Nov 1;208(2):99-106. doi: 10.1016/j.jsb.2019.08.005. Epub, 2019 Aug 13. PMID:31419524 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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