| Structural highlights
Function
FUCT_HELPX Involved in the biosynthesis of the Lewis X (LeX) trisaccharide of the lipopolysaccharide (LPS) O-antigen. Catalyzes the addition of fucose in alpha 1-3 linkage to Gal-beta-1-4-GlcNAc-beta-O-R (LacNAc-R) type II acceptor.[1] [2] [3] [4] [5]
References
- ↑ Ma B, Wang G, Palcic MM, Hazes B, Taylor DE. C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer. J Biol Chem. 2003 Jun 13;278(24):21893-900. doi: 10.1074/jbc.M301704200. Epub, 2003 Apr 3. PMID:12676935 doi:https://dx.doi.org/10.1074/jbc.M301704200
- ↑ Ma B, Lau LH, Palcic MM, Hazes B, Taylor DE. A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori {alpha}1,3/4 fucosyltransferase determines substrate specificity. J Biol Chem. 2005 Nov 4;280(44):36848-56. doi: 10.1074/jbc.M504415200. Epub 2005 , Sep 2. PMID:16150700 doi:https://dx.doi.org/10.1074/jbc.M504415200
- ↑ Lin SW, Yuan TM, Li JR, Lin CH. Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability. Biochemistry. 2006 Jul 4;45(26):8108-16. doi: 10.1021/bi0601297. PMID:16800635 doi:https://dx.doi.org/10.1021/bi0601297
- ↑ Sun HY, Lin SW, Ko TP, Pan JF, Liu CL, Lin CN, Wang AH, Lin CH. Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design. J Biol Chem. 2007 Mar 30;282(13):9973-82. Epub 2007 Jan 24. PMID:17251184 doi:https://dx.doi.org/10.1074/jbc.M610285200
- ↑ Ge Z, Chan NW, Palcic MM, Taylor DE. Cloning and heterologous expression of an alpha1,3-fucosyltransferase gene from the gastric pathogen Helicobacter pylori. J Biol Chem. 1997 Aug 22;272(34):21357-63. PMID:9261149
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