6adq

Respiratory Complex CIII2CIV2SOD2 from Mycobacterium smegmatis

Loading... Status: waiting for Mol* initialization Structural highlights 6adq is a 20 chain structure with sequence from Mycolicibacterium smegmatis MC2 51. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.5Å Ligands: 9XX, 9Y0, 9YF, CDL, CU, FES, HEA, HEC, HEM, MQ9, PLM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0R057_MYCS2 Publication Abstract from PubMed We report a 3.5-A resolution cryo-EM structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate such that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV via a bridging cytochrome subunit. We observe a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for development of treatments for human tuberculosis. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.,Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z Science. 2018 Oct 25. pii: science.aat8923. doi: 10.1126/science.aat8923. PMID:30361386 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cytochrome c oxidase 3D structures Superoxide dismutase 3D structures

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