6alk

NMR solution structure of the major beech pollen allergen Fag s 1

spinqualitylabelsall models 6alk Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6alk is a 1 chain structure with sequence from Fagus sylvatica. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B7TWE6_FAGSY Publication Abstract from PubMed Fag s 1 is a member of the Pathogen Related protein family 10 (PR-10) and can elicit cross-reaction with IgE antibodies produced against the birch pollen allergen Bet v 1. The Nuclear Magnetic Resonance (NMR) structure of Fag s 1 is presented along with its dynamic properties. It shares 66% identity with Bet v 1 and exhibits the expected three alpha-helices and seven beta-sheets arranged as a semi-beta barrel and exposing the residues mapped as the Bet v 1 IgE epitope. The structural dynamics of Fag s 1 were monitored on the fast and intermediate timescales, using relaxation rates. The complex dynamics of Fag s 1 are closely related to the internal cavity, and they modulate IgE and ligand binding. Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1.,Moraes AH, Asam C, Almeida FCL, Wallner M, Ferreira F, Valente AP Sci Rep. 2018 Jul 12;8(1):10512. doi: 10.1038/s41598-018-28358-1. PMID:30002383 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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