6azd

Crystal structure of Physcomitrella patens KAI2-like H

spinqualitylabelsall models 6azd, resolution 1.97Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6azd is a 1 chain structure with sequence from Physcomitrium patens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.9701074Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A9SG07_PHYPA Publication Abstract from PubMed In plants, strigolactones are perceived by the dual receptor-hydrolase DWARF14 (D14). D14 belongs to the superfamily of alpha/beta hydrolases and is structurally similar to the karrikin receptor KARRIKIN INSENSITIVE 2 (KAI2). The moss Physcomitrella patens is an ideal model system for studying this receptor family, because it includes 11 highly related family members with unknown ligand specificity. We present the crystal structures of three Physcomitrella D14/KAI2-like proteins and describe a loop-based mechanism that leads to a permanent widening of the hydrophobic substrate gorge. We have identified protein clades that specifically perceive the karrikin KAR1 and the non-natural strigolactone isomer (-)-5-deoxystrigol in a highly stereoselective manner. Structural Basis of Karrikin and Non-natural Strigolactone Perception in Physcomitrella patens.,Burger M, Mashiguchi K, Lee HJ, Nakano M, Takemoto K, Seto Y, Yamaguchi S, Chory J Cell Rep. 2019 Jan 22;26(4):855-865.e5. doi: 10.1016/j.celrep.2019.01.003. PMID:30673608 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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