6bi4

2.9 Angstrom Resolution Crystal Structure of dTDP-Glucose 4,6-dehydratase (rfbB) from Bacillus anthracis str. Ames in Complex with NAD.

spinqualitylabelsall models 6bi4, resolution 2.91Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bi4 is a 4 chain structure with sequence from Bacillus anthracis str. Ames. This structure supersedes the now removed PDB entry 4egb. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.91Å Ligands: FRU, GLC, MSE, NAD, NI, PRD_900003, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A6L7HMN5_BACAN Publication Abstract from PubMed Many bacteria require l-rhamnose as a key cell wall component. This sugar is transferred to the cell wall using an activated donor dTDP-l-rhamnose, which is produced by the dTDP-l-rhamnose biosynthetic pathway. We determined the crystal structure of the second enzyme of this pathway dTDP-alpha-d-glucose 4,6-dehydratase (RfbB) from Bacillus anthracis. Interestingly, RfbB only crystallized in the presence of the third enzyme of the pathway RfbC; however, RfbC was not present in the crystal. Our work represents the first complete structural characterization of the four proteins of this pathway in a single Gram-positive bacterium. Structure of the Bacillus anthracis dTDP-l-rhamnose biosynthetic pathway enzyme: dTDP-alpha-d-glucose 4,6-dehydratase, RfbB.,Gokey T, Halavaty AS, Minasov G, Anderson WF, Kuhn ML J Struct Biol. 2018 May;202(2):175-181. doi: 10.1016/j.jsb.2018.01.006. Epub 2018 , Jan 10. PMID:29331609 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also DTDP-glucose 4%2C6-dehydratase

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