6bzt

Crystal structure of halogenase PltM L111Y mutant in complex with FAD

spinqualitylabelsall models 6bzt, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6bzt is a 4 chain structure with sequence from Pseudomonas protegens Pf-5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: BR, CA, CL, FAD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q4KCZ3_PSEF5 Publication Abstract from PubMed Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase. Unusual substrate and halide versatility of phenolic halogenase PltM.,Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV Nat Commun. 2019 Mar 19;10(1):1255. doi: 10.1038/s41467-019-09215-9. PMID:30890712 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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