6c07

Crystal Structure of S-Adenosylmethionine synthetase (MetK/Mat) from Cryptosporidium parvum

spinqualitylabelsall models 6c07, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6c07 is a 4 chain structure with sequence from Cryptosporidium parvum Iowa II. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.85Å Ligands: CL, K, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5CYE4_CRYPI Catalyzes the formation of S-adenosylmethionine from methionine and ATP.[RuleBase:RU000541] Publication Abstract from PubMed S-Adenosyl-L-methionine (AdoMet), the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group-transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism, and disruption of its synthesis has adverse consequences for all forms of life. The family of AdoMet synthetases is highly conserved, and structures of this enzyme have been determined from organisms ranging from bacteria to humans. Here, the structure of an AdoMet synthetase from the infectious parasite Cryptosporidium parvum has been determined as part of an effort to identify structural differences in this enzyme family that can guide the development of species-selective inhibitors. This enzyme form has a less extensive subunit interface than some previously determined structures, and contains some key structural differences from the human enzyme in an allosteric site, presenting an opportunity for the design of selective inhibitors against the AdoMet synthetase from this organism. Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.,Ohren J, Parungao GG, Viola RE Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):290-298. doi:, 10.1107/S2053230X19002772. Epub 2019 Apr 2. PMID:30950830 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also S-adenosylmethionine synthetase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA