6c0v

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

Loading... Status: waiting for Mol* initialization Structural highlights 6c0v is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.4Å Ligands: ATP, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease MDR1_HUMAN Ulcerative colitis. Disease susceptibility is associated with variations affecting the gene represented in this entry. Function MDR1_HUMAN Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

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