| Structural highlights
Function
LECA_DIOLA D-mannose-binding lectin that also binds alpha-methyl-D-mannoside with even higher affinity (PubMed:24008245). Has hemagglutinating activity against rabbit erythrocytes (PubMed:24008245). Shows toxicity against the brine shrimp A.nauplii (PubMed:24008245). Induces reversible paw edema and hypernociceptivity in rats (PubMed:28196677).[1] [2]
References
- ↑ Pinto-Júnior VR, de Santiago MQ, Osterne VJ, Correia JL, Pereira-Júnior FN, Cajazeiras JB, de Vasconcelos MA, Teixeira EH, do Nascimento AS, Miguel TB, Miguel Ede C, Sampaio AH, do Nascimento KS, Nagano CS, Cavada BS. Purification, partial characterization and immobilization of a mannose-specific lectin from seeds of Dioclea lasiophylla mart. Molecules. 2013 Sep 4;18(9):10857-69. PMID:24008245 doi:10.3390/molecules180910857
- ↑ Pinto-Junior VR, Osterne VJS, Santiago MQ, Lossio CF, Nagano CS, Rocha CRC, Nascimento JCF, Nascimento FLF, Silva IB, Oliveira AS, Correia JLA, Leal RB, Assreuy AMS, Cavada BS, Nascimento KS. Molecular modeling, docking and dynamics simulations of the Dioclea lasiophylla Mart. Ex Benth seed lectin: An edematogenic and hypernociceptive protein. Biochimie. 2017 Apr;135:126-136. PMID:28196677 doi:10.1016/j.biochi.2017.02.002
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