6dj8

Structure of DNA polymerase III subunit beta from Borrelia burgdorferi in complex with a natural product

spinqualitylabelsall models 6dj8, resolution 2.05Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6dj8 is a 4 chain structure with sequence from Borreliella burgdorferi B31 and Streptomyces. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.05Å Ligands: ACE, MLU, MP8, MVA, NZC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DPO3B_BORBU Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988] See Also DNA polymerase 3D structures

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