6dsx

Bst DNA polymerase I post-chemistry (n+1 with dATP soak) structure

spinqualitylabelsall models 6dsx, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6dsx is a 3 chain structure with sequence from Geobacillus stearothermophilus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.99Å Ligands: MG, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function E1C9K5_GEOSE Publication Abstract from PubMed High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site. Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.,Chim N, Jackson LN, Trinh AM, Chaput JC Elife. 2018 Oct 19;7. pii: 40444. doi: 10.7554/eLife.40444. PMID:30338759 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also DNA polymerase 3D structures

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