6dte

GlcNAc-inspired cyclophellitol bound to NagZ

spinqualitylabelsall models 6dte, resolution 1.93Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6dte is a 2 chain structure with sequence from Burkholderia cenocepacia. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.929Å Ligands: H9J Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A125HFC0_9BURK Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.[HAMAP-Rule:MF_00364][SAAS:SAAS00634279] Publication Abstract from PubMed The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC beta-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important beta-lactams against a clinically relevant strain of Pseudomonas aeruginosa. A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa.,Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub, 2018 Sep 4. PMID:30178799 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Beta-Hexosaminidase Beta-Hexosaminidase 3D structures Beta-N-acetylhexosaminidase 3D structures

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