6e0o

Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with pppA[3'-5']pA

spinqualitylabelsall models 6e0o, resolution 1.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6e0o is a 3 chain structure with sequence from Elizabethkingia meningoseptica ATCC 13253 = NBRC 12535. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.25Å Ligands: ATP, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CDNE_ELIME CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type I-A(GA) CBASS system (PubMed:32839535). Cyclic dinucleotide synthase that catalyzes the synthesis of 3'3'-cyclic GMP-AMP (cGAMP) from GTP and ATP, and of c-di-AMP and c-di-GMP, that are second messengers for cell signal transduction.

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