6e37

O-GlcNAc Transferase in complex with covalent inhibitor

spinqualitylabelsall models 6e37, resolution 2.53Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6e37 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.531Å Ligands: HQV Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect other functionally similar enzymes. This study provides a new strategy to interrogate cellular OGT functions and to investigate other glycosyltransferases. Targeted covalent inhibition of O-GlcNAc transferase in cells.,Worth M, Hu CW, Li H, Fan D, Estevez A, Zhu D, Wang A, Jiang J Chem Commun (Camb). 2019 Oct 31;55(88):13291-13294. doi: 10.1039/c9cc04560k. PMID:31626249 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also O-GlcNAc transferase 3D structures

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