6ekv

Structure of OrfX2 from Clostridium botulinum A2

spinqualitylabelsall models 6ekv, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ekv is a 1 chain structure with sequence from Clobj. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 NonStd Res: MSE Gene: CLM_0892 (CLOBJ) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Botulinum neurotoxins are highly toxic substances and are all encoded together with one of two alternative gene clusters, the HA or the OrfX gene cluster. Very little is known about the function and structure of the proteins encoded in the OrfX gene cluster, which in addition to the toxin contains five proteins (OrfX1, OrfX2, OrfX3, P47, and NTNH). We here present the structures of OrfX2 and P47, solved to 2.1 and 1.8 A, respectively. We show that they belong to the TULIP protein superfamily, which are often involved in lipid binding. OrfX1 and OrfX2 were both found to bind phosphatidylinositol lipids. Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster.,Gustafsson R, Berntsson RP, Martinez-Carranza M, El Tekle G, Odegrip R, Johnson EA, Stenmark P FEBS Lett. 2017 Oct 25. doi: 10.1002/1873-3468.12889. PMID:29067689 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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