6g7c

Nt2-CTD domains of the TssA component from the type VI secretion system of Aeromonas hydrophila.

spinqualitylabelsall models 6g7c, resolution 3.13Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6g7c is a 10 chain structure with sequence from Aeromonas hydrophila subsp. hydrophila ATCC 7966. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.13Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0KJC7_AERHH Publication Abstract from PubMed The type VI secretion system (T6SS) is a multi-protein complex that injects bacterial effector proteins into target cells. It is composed of a cell membrane complex anchored to a contractile bacteriophage tail-like apparatus consisting of a sharpened tube that is ejected by the contraction of a sheath against a baseplate. We present structural and biochemical studies on TssA subunits from two different T6SSs that reveal radically different quaternary structures in comparison to the dodecameric E. coli TssA that arise from differences in their C-terminal sequences. Despite this, the different TssAs retain equivalent interactions with other components of the complex and position their highly conserved N-terminal ImpA_N domain at the same radius from the centre of the sheath as a result of their distinct domain architectures, which includes additional spacer domains and highly mobile interdomain linkers. Together, these variations allow these distinct TssAs to perform a similar function in the complex. Structural insights into the function of type VI secretion system TssA subunits.,Dix SR, Owen HJ, Sun R, Ahmad A, Shastri S, Spiewak HL, Mosby DJ, Harris MJ, Batters SL, Brooker TA, Tzokov SB, Sedelnikova SE, Baker PJ, Bullough PA, Rice DW, Thomas MS Nat Commun. 2018 Nov 12;9(1):4765. doi: 10.1038/s41467-018-07247-1. PMID:30420757 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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