6gyb

Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri

Loading... Status: waiting for Mol* initialization Structural highlights 6gyb is a 42 chain structure with sequence from Xanthomonas citri pv. citri str. 306. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.28Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Type IV secretion (T4S) systems form the most common and versatile class of secretion systems in bacteria, capable of injecting both proteins and DNAs into host cells. T4S systems are typically composed of 12 components that form 2 major assemblies: the inner membrane complex embedded in the inner membrane and the core complex embedded in both the inner and outer membranes. Here we present the 3.3 A-resolution cryo-electron microscopy model of the T4S system core complex from Xanthomonas citri, a phytopathogen that utilizes this system to kill bacterial competitors. An extensive mutational investigation was performed to probe the vast network of protein-protein interactions in this 1.13-MDa assembly. This structure expands our knowledge of the molecular details of T4S system organization, assembly and evolution. Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri.,Sgro GG, Costa TRD, Cenens W, Souza DP, Cassago A, Coutinho de Oliveira L, Salinas RK, Portugal RV, Farah CS, Waksman G Nat Microbiol. 2018 Oct 22. pii: 10.1038/s41564-018-0262-z. doi:, 10.1038/s41564-018-0262-z. PMID:30349081 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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