6hzy

Crystal structure of a bacterial fucosidase with inhibitor FucPUG

spinqualitylabelsall models 6hzy, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6hzy is a 2 chain structure with sequence from Bacteroides thetaiotaomicron VPI-5482. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: EDO, GYZ, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q8A3I4_BACTN Publication Abstract from PubMed The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, alpha-L-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel alpha-L-fucosidase inhibitors, with X-ray crystallographic analysis using an alpha-L-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class. Synthetic and crystallographic insight into exploiting sp2-hybridization in the development of alpha-L-fucosidase inhibitors.,Coyle T, Wu L, Debowski A, Davies G, Stubbs KA Chembiochem. 2019 Jan 21. doi: 10.1002/cbic.201800710. PMID:30663832 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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