6i0r

Structure of quinolinate synthase in complex with 5-mercaptopyridine-2,3-dicarboxylic acid

spinqualitylabelsall models 6i0r, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6i0r is a 1 chain structure with sequence from Thermotoga maritima MSB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: FE, H2S, QAT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NADA_THEMA Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity). Publication Abstract from PubMed Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme. Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.,Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clemancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S Chem Commun (Camb). 2019 Mar 11. doi: 10.1039/c8cc09023h. PMID:30855610 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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