6i3h

Crystal structure of influenza A virus M1 N-terminal domain (G18A mutation)

spinqualitylabelsall models 6i3h, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6i3h is a 2 chain structure with sequence from Influenza A virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.9Å Ligands: PO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function M1_I33A0 Publication Abstract from PubMed Influenza A virus is a pathogen of great medical impact. To develop novel antiviral strategies, it is essential to understand the molecular aspects of virus-host cell interactions in detail. During entry, the viral ribonucleoproteins (vRNPs) that carry the RNA genome must be released from the incoming particle before they can enter the nucleus for replication. The uncoating process is facilitated by histone deacetylase 6 (ref.(1)). However, the precise mechanism of shell opening and vRNP debundling is unknown. Here, we show that transportin 1, a member of the importin-beta family proteins, binds to a PY-NLS(2) sequence motif close to the amino terminus of matrix protein (M1) exposed during acid priming of the viral core. It promotes the removal of M1 and induces disassembly of vRNP bundles. Next, the vRNPs interact with importin-alpha/beta and enter the nucleus. Thus, influenza A virus uses dual importin-betas for distinct steps in host cell entry. Influenza virus uses transportin 1 for vRNP debundling during cell entry.,Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y Nat Microbiol. 2019 Apr;4(4):578-586. doi: 10.1038/s41564-018-0332-2. Epub 2019 , Jan 28. PMID:30692667 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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