6jv7

Chimeric Rat C5a

spinqualitylabelsall models 6jv7, resolution 1.31Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6jv7 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.309Å Ligands: ALN, DAL, DAR, DAS, DCY, DGL, DGN, DHI, DIL, DLE, DLY, DPN, DPR, DSG, DSN, DTH, DTY, DVA, MED, ORN, SO4, ZAL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CO5_RAT Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.[UniProtKB:P01031] See Also Complement C5 3D structures

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