6k6u

Crystal structure of the human YTHDC2 YTH domain

spinqualitylabelsall models 6k6u, resolution 2.27Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6k6u is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.27Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function YTDC2_HUMAN Publication Abstract from PubMed N(6)-methyladenosine (m(6)A) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the m(6)A readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted m(6)A RNA. However, how YTH domain of YTHDC2 recognize m(6)A RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved m(6)A binding pocket, and similar RNA binding surface shared by YTHDC1. Crystal structure of human YTHDC2 YTH domain.,Ma C, Liao S, Zhu Z Biochem Biophys Res Commun. 2019 Oct 22;518(4):678-684. doi:, 10.1016/j.bbrc.2019.08.107. Epub 2019 Aug 28. PMID:31472957 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA