6ke2

ABloop reengineered Ferritin Nanocage

spinqualitylabelsall models 6ke2, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ke2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.798Å Ligands: CA, CL, FE, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function FRIH_HUMAN Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Publication Abstract from PubMed Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH </= 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.,Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H Chem Commun (Camb). 2019 Oct 10;55(82):12344-12347. doi: 10.1039/c9cc05247j. PMID:31556881 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ferritin 3D structures

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