6kh5

Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes

spinqualitylabelsall models 6kh5, resolution 2.29Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6kh5 is a 1 chain structure with sequence from Penaeus japonicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.294Å Ligands: FE, NI Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function T2B7E1_PENJP Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] Publication Abstract from PubMed Metal-organic frameworks (MOFs) hold great promise for numerous applications. However, proteins, carriers of biological functions in living systems, have not yet been fully explored as building blocks for the construction of MOFs. Here, we presented a strategy for the fabrication of binary MOFs. Considering octahedral ferritin symmetry, we firstly incorporated four His 2 (His-His) motifs into the exterior surface of ferritin nanocage nearby each C 4 channel, yielding protein linkers with multiple metal binding sites (bisH-SF). Secondly, by adding nickel ions to bisH-SF solutions to triggers the self-assembly of ferritin nanocages into a porous 3D crystalline MOF with designed protein lattice, where two adjacent ferritin molecules along the C 4 symmetry axes are bridged by four dinuclear or tetranuclear nickel clusters depending on Ni 2+ concentration. This work provides a simple approach for precise control over a binary protein-metal crystalline framework, and resulting MOFs exhibited inherent ferroxidase activity and peroxidase-like catalytic activity. Structural Insight into Binary Protein MOFs with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.,Gu C, Chen H, Wang Y, Zhang T, Wang H, Zhao G Chemistry. 2019 Dec 9. doi: 10.1002/chem.201905315. PMID:31820500 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ferritin 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA