6ko8

Crystal structure of the Cholic acid bound RamR determined with XtaLAB Synergy

spinqualitylabelsall models 6ko8, resolution 1.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ko8 is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.55Å Ligands: CHD, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q8ZR43_SALTY Publication Abstract from PubMed The structure determination of organic compounds is desirable for the development of medicines, aroma chemicals, and agricultural chemicals. However, the crystallization of organic compounds is often troublesome, because crystallization requires a relatively large quantity of high purity compounds and crystallization trials often need to be performed repetitively using different conditions. Some proteins are known to be able to bind to various organic compounds. The multidrug-resistance regulator protein RamR is one such protein. We have developed a structure determination method for organic compounds using RamR. RamR bound to organic compounds, including one compound that was not a known ligand for RamR, and the structures of the complexes were successfully determined. Because the RamR crystal is hydrophilic, this method may be useful for compounds that cannot be handled by the crystalline sponge method. Development of a structure determination method using a multidrug-resistance regulator protein as a framework.,Matsumoto T, Nakashima R, Yamano A, Nishino K Biochem Biophys Res Commun. 2019 Oct 15;518(2):402-408. doi:, 10.1016/j.bbrc.2019.08.070. Epub 2019 Aug 17. PMID:31431261 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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