Structural highlights
6kzf is a 2 chain structure with sequence from Dendroaspis angusticeps. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.52Å |
| Ligands: | ABA, DAL, DAR, DCY, DGL, DGN, DIL, DLE, DLY, DPN, DPR, DSG, DSN, DTH, DTR, DTY, DVA |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
VKTHC_DENAN Potent blocker of high-voltage-activated calcium ion channels in the nanomolar range, particularly the L-type channels in cerebellar granule cells. The sensitivity of L-, N- and P-type channels to CAC is tissue and species-dependent. Blocks the L-type current of cardiac cells, depressing cardiac contractility.
