6lpe
Phascolosoma esculenta ferritin
Structural highlights
FunctionB3TFG2_9BILA Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[ARBA:ARBA00002716] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.[RuleBase:RU361145] Publication Abstract from PubMedFor marine invertebrates with no adaptive immune system, ferritin is a major intracellular iron-storage protein with a critical role in innate immunity. Here, we present the crystal structures of two novel ferritins (Fer147 and PeFer) from the marine invertebrate Phascolosoma esculenta, which resides in muddy-bottom coastal regions. Fer147 and PeFer exhibit the 4-3-2 symmetry of cage-like hollow shells containing 24 subunits, similar to other known ferritins. Fer147 and PeFer contain both the conserved ferroxidase center and 3-fold channels. Subtle structural differences in the putative nucleation sites suggest possible routes of metal ion movement in the protein shells. However, the marked variation in the electrostatic potential of the 3-fold channels in Fer147 and the 4-fold channels in PeFer suggest significant diversity between Fer147 and PeFer in terms of metal ion aggregation and cation exclusion. In summary, the presented crystal structures may serve as references for studies of the iron storage mechanism of additional ferritins from marine invertebrates. Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta.,Ming T, Huan H, Su C, Huo C, Wu Y, Jiang Q, Qiu X, Lu C, Zhou J, Li Y, Su X FEBS Open Bio. 2021 Jan 15. doi: 10.1002/2211-5463.13080. PMID:33448656[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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