6lus

Crystal structure of the Mengla Virus VP30 C-terminal domain

spinqualitylabelsall models 6lus, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6lus is a 1 chain structure with sequence from Mengla dianlovirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A3S8UVN5_9MONO Publication Abstract from PubMed The family Filoviridae contains many important human viruses, including Marburg virus (MARV) and Ebola virus (EBOV). Mengla virus (MLAV), a newly discovered filovirus, is considered a potential human pathogen. The VP30 C-terminal domain (CTD) of these filoviruses plays an essential role in virion assembly. In common with other filoviruses, MLAV VP30 CTD mainly exists as a dimer in solution. In this work, we determined the crystal structure of recombinant MLAV VP30 CTD monomer, verifying that C-terminal helix-7 (H7) is critical for the dimerization process. This study provides a preliminary model for investigation of MLAV VP30 CTD as an anti-filovirus drug development target. Crystal structure of the Mengla virus VP30 C-terminal domain.,Dong S, Wen K, Chu H, Li H, Yu Q, Wang C, Qin X Biochem Biophys Res Commun. 2020 Apr 30;525(2):392-397. doi: , 10.1016/j.bbrc.2020.02.089. Epub 2020 Feb 22. PMID:32093889 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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