6lx3

Cryo-EM structure of human secretory immunoglobulin A

spinqualitylabelsall models 6lx3, resolution 3.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.15Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. How the J-chain and pIgR/SC facilitate the assembly and secretion of SIgA remains incompletely understood. Furthermore, during the infection of Streptococcus pneumoniae, the pneumococcal adhesin SpsA hijacks pIgR/SC and SIgA to gain entry to human cells and evade host defense. How SpsA targets pIgR/SC and SIgA also remains elusive. Here we report a cryo-electron microscopy structure of the Fc region of IgA1 (Fcalpha) in complex with the J-chain and SC (Fcalpha-J-SC), which reveals the organization principle of SIgA. We also present a structure of Fcalpha-J-SC complexed with SpsA, which uncovers the specific interactions between SpsA and human pIgR/SC. These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis. Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.,Wang Y, Wang G, Li Y, Zhu Q, Shen H, Gao N, Xiao J Cell Res. 2020 May 12. pii: 10.1038/s41422-020-0336-3. doi:, 10.1038/s41422-020-0336-3. PMID:32398862 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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