6nsj

CryoEM structure of Helicobacter pylori urea channel in closed state

Loading... Status: waiting for Mol* initialization Structural highlights 6nsj is a 6 chain structure with sequence from Helicobacter pylori J99. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.7Å Ligands: XP4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function UREI_HELPJ Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below (By similarity). See Also Urease accessory protein 3D structures

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