6otb | pdb_00006otb

NMR structure of alpha conotoxin SII

spinqualitylabelsall models 6otb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6otb is a 1 chain structure with sequence from Conus striatus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CAS2_CONST Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:1390774). This toxin potently inhibits the rodent muscle nAChR (IC(50)=120 nM (adult subtype, alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and IC(50)=370 nM (fetal subtype, alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND)) and weakly inhibits neuronal nAChRs (PubMed:35357806). In contrast to alpha-conotoxins bearing 2 disulfide bonds (framework I), this conotoxin acts via a unique binding mode with the helix and the N- and C-termini buried in the binding pocket of muscle nAChRs (PubMed:35357806).

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