6q68

Crystal structure of bovine ACBD3 GOLD domain in complex with 3A protein of enterovirus-F2 (fusion protein)

spinqualitylabelsall models 6q68, resolution 3.16Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6q68 is a 4 chain structure with sequence from Bos taurus and Enterovirus F. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.161Å Ligands: BGC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function F1MRE5_BOVIN Publication Abstract from PubMed Picornaviruses infect a wide range of mammals including livestock such as cattle and swine. As with other picornavirus genera such as Aphthovirus, there is emerging evidence of a significant economic impact of livestock infections caused by members of the genera Enterovirus and Kobuvirus. While the human-infecting enteroviruses and kobuviruses have been intensively studied during the past decades in great detail, research on livestock-infecting viruses has been mostly limited to the genomic characterization of the viral strains identified worldwide. Here, we extend our previous studies of the structure and function of the complexes composed of the non-structural 3A proteins of human-infecting enteroviruses and kobuviruses and the host ACBD3 protein and present a structural and functional characterization of the complexes of the following livestock-infecting picornaviruses: bovine enteroviruses EV-E and EV-F, porcine enterovirus EV-G, and porcine kobuvirus AiV-C. We present a series of crystal structures of these complexes and demonstrate the role of these complexes in facilitation of viral replication. Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses.,Smola M, Horova V, Boura E, Klima M Arch Virol. 2019 Dec 16. pii: 10.1007/s00705-019-04490-9. doi:, 10.1007/s00705-019-04490-9. PMID:31845156 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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