6r2x

NMR structure of Chromogranin A (F39-D63)

spinqualitylabelsall models 6r2x Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6r2x is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CMGA_HUMAN Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. Publication Abstract from PubMed Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for alphavbeta6 and alphavbeta8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications. A stapled chromogranin A-derived peptide is a potent dual ligand for integrins alphavbeta6 and alphavbeta8.,Nardelli F, Ghitti M, Quilici G, Gori A, Luo Q, Berardi A, Sacchi A, Monieri M, Bergamaschi G, Bermel W, Chen F, Corti A, Curnis F, Musco G Chem Commun (Camb). 2019 Nov 22. doi: 10.1039/c9cc08518a. PMID:31755501 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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