6riq

MinCD filament from Pseudomonas aeruginosa

Loading... Status: waiting for Mol* initialization Structural highlights 6riq is a 22 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.1Å Ligands: ATP, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MINC_PSEAE Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.[HAMAP-Rule:MF_00267] Publication Abstract from PubMed Positioning of the division site in many bacterial species relies on the MinCDE system, which prevents the cytokinetic Z-ring from assembling anywhere but the mid-cell, through an oscillatory diffusion-reaction mechanism. MinD dimers bind to membranes and, via their partner MinC, inhibit the polymerization of cell division protein FtsZ into the Z-ring. MinC and MinD form polymeric assemblies in solution and on cell membranes. Here, we report the high-resolution cryo-EM structure of the copolymeric filaments of Pseudomonas aeruginosa MinCD. The filaments consist of three protofilaments made of alternating MinC and MinD dimers. The MinCD protofilaments are almost completely straight and assemble as single protofilaments on lipid membranes, which we also visualized by cryo-EM. Cryo-EM structure of the MinCD copolymeric filament from Pseudomonas aeruginosa at 3.1 A resolution.,Szewczak-Harris A, Wagstaff J, Lowe J FEBS Lett. 2019 Jun 5. doi: 10.1002/1873-3468.13471. PMID:31166018 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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