6rnl

L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)

spinqualitylabelsall models 6rnl, resolution 1.88Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6rnl is a 4 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.88Å Ligands: K, NA, RKL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Lambda-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed from terminal T.A and T.T mismatched pairs. A third shows kinking by a TAP ligand between T.T linkages, while the fourth shows sandwiching of a dppz ligand between a T.A/T.A quadruplex and a T.T mismatch, stabilised by an additional T.A base pair stacking interaction on a TAP surface. Overall, the structure shows an unexpected affinity for thymine, and suggests models for G-quadruplex loop binding. Three thymine/adenine binding modes of the ruthenium complex Lambda-[Ru(TAP)(2)(dppz)](2+) to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography.,McQuaid K, Hall JP, Baumgaertner L, Cardin DJ, Cardin CJ Chem Commun (Camb). 2019 Jul 30;55(62):9116-9119. doi: 10.1039/c9cc04316k. PMID:31298665 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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