6rp5

Crystal structure of monocarboxylated hemoglobin from the sub-Antarctic fish Eleginops maclovinus

spinqualitylabelsall models 6rp5, resolution 1.49Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6rp5 is a 2 chain structure with sequence from Eleginops maclovinus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.49Å Ligands: ACE, CMO, DTN, HEM, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function HBA1_ELEMC Publication Abstract from PubMed Tetrameric hemoglobins (Hbs) are prototypical systems for the investigations of fundamental properties of proteins. Although the structure of these proteins has been known for nearly sixty years, there are many aspects related to their function/structure that are still obscure. Here, we report the crystal structure of a carbonmonoxy form of the Hb isolated from the sub-Antarctic notothenioid fish Eleginops maclovinus characterised by either rare or unique features. In particular, the distal site of the alpha chain results to be very unusual since the distal His is displaced from its canonical position. This displacement is coupled with a shortening of the highly conserved E helix and the formation of novel interactions at tertiary structure level. Interestingly, the quaternary structure is closer to the T-deoxy state of Hbs than to the R-state despite the full coordination of all chains. Notably, these peculiar structural features provide a rationale for some spectroscopic properties exhibited by the protein in solution. Finally, this unexpected structural plasticity of the heme distal side has been associated with specific sequence signatures of various Hbs. The unique structural features of carbonmonoxy hemoglobin from the sub-Antarctic fish Eleginops maclovinus.,Balasco N, Vitagliano L, Merlino A, Verde C, Mazzarella L, Vergara A Sci Rep. 2019 Dec 12;9(1):18987. doi: 10.1038/s41598-019-55331-3. PMID:31831781 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Hemoglobin 3D structures

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