6s7v | pdb_00006s7v

Lipoteichoic acids flippase LtaA

spinqualitylabelsall models 6s7v, resolution 3.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6s7v is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: BTN44_07740, FA040_03480, RK64_05390 ("Micrococcus aureus" (Rosenbach 1884) Zopf 1885) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA biogenesis. Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions. Our results provide foundations for the development of new strategies to counteract S. aureus infections. Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.,Zhang B, Liu X, Lambert E, Mas G, Hiller S, Veening JW, Perez C Nat Struct Mol Biol. 2020 May 4. pii: 10.1038/s41594-020-0425-5. doi:, 10.1038/s41594-020-0425-5. PMID:32367070 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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