6t96

Photorhabdus laumondii subsp. laumondii lectin PLL3

spinqualitylabelsall models 6t96, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6t96 is a 1 chain structure with sequence from Photorhabdus laumondii subsp. laumondii TTO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.65Å Ligands: CSO, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q7N8I7_PHOLL Publication Abstract from PubMed The Photorhabdus species is a Gram-negative bacteria of the family Morganellaceae that is known for its mutualistic relationship with Heterorhabditis nematodes and pathogenicity toward insects. This study is focused on the characterization of the recombinant lectin PLL3 with an origin in P. laumondii subsp. laumondii. PLL3 belongs to the PLL family of lectins with a seven-bladed beta-propeller fold. The binding properties of PLL3 were tested by hemagglutination assay, glycan array, isothermal titration calorimetry, and surface plasmon resonance, and its structure was determined by X-ray crystallography. Obtained data revealed that PLL3 binds similar carbohydrates to those that the other PLL family members bind, with some differences in the binding properties. PLL3 exhibited the highest affinity toward l-fucose and its derivatives but was also able to interact with O-methylated glycans and other ligands. Unlike the other members of this family, PLL3 was discovered to be a monomer, which might correspond to a weaker avidity effect compared to homologous lectins. Based on the similarity to the related lectins and their proposed biological function, PLL3 might accompany them during the interaction of P. laumondii with both the nematode partner and the insect host. Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed beta-Propeller Lectin Family.,Faltinek L, Fujdiarova E, Melicher F, Houser J, Kasakova M, Kondakov N, Kononov L, Parkan K, Vidal S, Wimmerova M Molecules. 2019 Dec 11;24(24). pii: molecules24244540. doi:, 10.3390/molecules24244540. PMID:31835851 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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