6ti3
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Apo-SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with D-Threonine
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Structural highlights
FunctionGLYA_STRT1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. See AlsoContents | ||||||||||||||||||||
This page was last modified 13:02, 24 January 2024.