6tza
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CryoEM reconstruction of ESCRT-III filament composed of IST1 NTD R16E K27E double mutant
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Structural highlights
FunctionIST1_HUMAN Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.[1] [2] See AlsoReferences
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This page was last modified 09:28, 20 March 2024.